Elevated homocysteine is a major risk factor for heart disease and cognitive decline. B6, B12, and folate work together in the methylation cycle to clear it. The cycle requires all three -- none alone is sufficient.
Combined formula with P5P (active B6), methylcobalamin (active B12), and methylfolate (active folate). Uses the bioavailable methylated forms that bypass common genetic conversion bottlenecks like MTHFR variants.
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Coming soonHow to take this trio: Take 25-50 mg P5P (active B6), 1,000 mcg methylcobalamin (B12), and 400-800 mcg methylfolate together in the morning. Can be taken on an empty stomach or with breakfast. Sublingual B12 offers superior absorption. Do not exceed 100 mg/day of B6 long-term to avoid peripheral neuropathy. Use methylated forms rather than folic acid or cyanocobalamin for direct bioavailability.
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