People with MTHFR gene variants can't properly convert standard folic acid and B12. Methylfolate and methylcobalamin bypass the broken enzyme entirely, entering the methylation cycle directly.
Pre-methylated forms of both nutrients: methylcobalamin B12 and methylfolate (5-MTHF). Bypasses the MTHFR enzyme entirely, so the active forms reach the methylation cycle without requiring conversion.
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Coming soonHow to take this pair: Take 1,000-5,000 mcg methylcobalamin B12 (sublingual absorbs best) with 400-1,000 mcg methylfolate in the morning. Can be taken on an empty stomach or with breakfast. Start methylfolate at a low dose (100-400 mcg) and increase gradually. Some people experience overmethylation symptoms (anxiety, irritability) at higher doses. Avoid synthetic folic acid if you have confirmed MTHFR variants.
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